![]() Nowadays, researchers and anesthesiologists know much more about the mechanisms underlying the effects of anesthetic drugs and how they produce the profound change in behavioral state that implies a total lack of perception. Because general anesthesia was such a game changer in medicine, these drugs were implemented in the operating room many decades before researchers understood how they worked. ![]() The practice of putting patients in a reversible coma-like state changed surgery to a humane and often life-saving therapy. ![]() Before the advent of general anesthesia in the mid-19th century, surgery was a traumatic experience for everyone involved-the patient, of course, but also the medical staff and anyone who happened to walk by the surgery room and could hear the screams. ![]()
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